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USC Neurovascular Center

USC Neurovascular Center

Protecting Your Brain with Precision and Expertise

When a neurovascular condition threatens your brain health, you deserve a team with the experience to guide your care. At the USC Neurovascular Center, our specialists treat stroke, brain aneurysms, arteriovenous malformations (AVMs), moyamoya disease and other complex disorders. We use advanced therapies to restore blood flow, protect brain function and help you achieve the best possible outcome.

Our multidisciplinary team includes vascular neurologists, cerebrovascular surgeons, interventional neurologists, neurocritical care physicians, rehabilitation specialists and other experts. Instead of working separately, we collaborate to review your condition from every angle. You’ll have a clear understanding of your diagnosis, treatment options and what to expect before making any decisions about your care.

Innovation is part of everything we do. As part of Keck Medicine of USC, our physicians lead research that continues to improve the diagnosis and treatment of neurovascular disease. Through clinical trials, eligible patients may have access to new therapies before they’re widely available. You can feel confident with a team that’s helping shape the future of neurovascular care.

Why Choose Us for Neurovascular Care

  • Multiple experts, one visit: We bring together specialists from across neurovascular care, allowing you to see multiple experts in one visit and receive a coordinated treatment plan.
  • A team that decides together: At our weekly multidisciplinary clinic, vascular neurologists, cerebrovascular surgeons, interventional neurologists and other specialists review your case together to recommend the best approach for your condition.
  • Treatment guided by precise imaging: We use the latest imaging and diagnostic technology to get a clear understanding of your condition and underlying risks before starting treatment.
  • Trusted for the most complex cases: As a high-volume specialized center that is focused on treating the most complex diseases, we care for patients with neurovascular conditions from across Southern California and beyond. Our nationally recognized team has decades of experience treating even the most challenging diagnoses.
  • Telestroke network: Our comprehensive stroke program includes a telestroke network that expands access to rapid evaluation and treatment across the region.
  • Comprehensive care from diagnosis through recovery: Whether it’s stroke prevention, a second opinion, minimally invasive treatment or long-term follow-up, you’ll have our unwavering care and support for every stage of your journey.

Conditions We Treat

  • Stroke and transient ischemic attack (TIA), including ischemic stroke and hemorrhagic stroke
  • Arteriovenous malformations (AVMs)
  • Brain aneurysms
  • Carotid and vertebral artery disease
  • Cavernous malformations
  • Cerebral small vessel disease
  • Cerebral vasculitis
  • Cerebral venous sinus thrombosis
  • Dural arteriovenous fistulas (dAVFs)
  • Embolic stroke of undetermined source (ESUS)
  • Intracranial atherosclerotic disease
  • Moyamoya disease
  • Patent foramen ovale (PFO)-related stroke
  • Post-stroke recovery complications
  • Reversible cerebral vasoconstriction syndrome (RCVS)
  • Vascular cognitive impairment

Treatments We Offer

  • Advanced neurovascular consultations: Our specialists evaluate complex neurovascular conditions, provide second opinions and develop personalized care plans based on your diagnosis, symptoms and goals.
  • Stroke prevention and medical management: We work to reduce your risk of stroke through personalized prevention strategies. Your plan may include medications that help prevent blood clots, such as antithrombotic and anticoagulation therapies.
  • Emergency stroke treatment: Our team quickly evaluates you for time-sensitive treatments, including intravenous thrombolysis (clot-busting medication) and mechanical thrombectomy.
  • Mechanical thrombectomy: For eligible patients experiencing an acute ischemic stroke, we perform this minimally invasive procedure to remove a blood clot and restore blood flow to the brain.
  • Endovascular procedures: Using tiny catheters inserted through the blood vessels, we perform minimally invasive treatments for neurovascular disease. Procedures include embolization, carotid artery interventions, stenting, aneurysm coiling and flow diversion.
  • Microsurgery for cerebrovascular disease: When surgery is the best option, our cerebrovascular surgeons perform advanced procedures to treat aneurysms, AVMs and other vascular disorders.
  • Rehabilitation and recovery support: Your care doesn’t end after treatment. We plan rehabilitation and long-term follow-up to help you regain function and reduce your risk of future complications.
  • Clinical trials: Eligible patients may have first access to innovative therapies and technologies for neurovascular conditions.

Screening and Diagnostics We Offer

These advanced tests help us diagnose neurovascular conditions, understand how blood flows through your brain and create your personalized treatment plan.

Magnetic Resonance Imaging (MRI) and Magnetic Resonance Angiography (MRA)

MRI uses magnets and radio waves to create detailed images of your brain. MRA focuses specifically on your blood vessels, helping us identify aneurysms, narrowed arteries and other neurovascular conditions without surgery.

Computed Tomography (CT) and CT Angiography (CTA)

CT scans use X-rays to create detailed images of your brain, while CTA uses contrast dye to produce detailed images of your blood vessels. These tests allow us to quickly diagnose stroke, bleeding, aneurysms and other vascular conditions.

CT Perfusion Imaging

Perfusion imaging measures how well blood is reaching different areas of your brain. It helps our specialists know which areas of the brain may be damaged and which areas we can still save after a stroke.

Catheter Cerebral Angiography (Digital Subtraction Angiography)

Often considered the gold standard for evaluating blood vessels in the brain, this minimally invasive procedure uses a small catheter and contrast dye to create highly detailed images. It helps us diagnose aneurysms, blockages and arteriovenous malformations (AVMs).

Vessel Wall MRI

Unlike a traditional MRI, this specialized scan looks at the walls of your blood vessels rather than just blood flow. We use it to identify inflammation and narrowing of the arteries.

Carotid Duplex Ultrasound

This painless ultrasound uses sound waves to evaluate blood flow through the carotid arteries in your neck. It helps identify narrowing or blockages that may increase your risk of stroke.

Transcranial Doppler Ultrasound

This noninvasive ultrasound monitors blood flow through the arteries inside your brain. We use it to detect narrowed blood vessels and assess your risk for stroke.

Multidisciplinary Imaging Review

Our specialists use advanced diagnostic technology, including artificial intelligence (AI)-assisted image analysis, to better understand your condition. By reviewing your results together, we can make a more accurate diagnosis and recommend the best possible treatment.

What to Expect at the Neurovascular Center

Referrals and Second Opinions

Referral requirements vary depending on your insurance. Many patients can schedule a neurovascular consultation directly. Referrals may come from a primary care provider, neurologist, neurosurgeon or another specialist.

Initial Assessment

Your first visit includes a thorough review of your medical history, symptoms, medications and any previous imaging or medical records. If we need more information, our specialists may recommend advanced imaging to confirm a diagnosis.

Personalized Care Planning

After your evaluation, providers from multiple specialties review your case together. We discuss your diagnosis, explain treatment options and answer questions so you can make informed decisions about your care.

Follow-Up Care

Your care continues after treatment with ongoing follow-up visits to monitor your progress and reduce your risk of future complications. When appropriate, we’ll coordinate rehabilitation as you regain function and return to everyday life.

Your Team

It takes comprehensive care to treat conditions affecting the blood vessels of the brain and central nervous system. That’s why we have a wide range of experts on our team, including:

  • Neurologists who diagnose and manage stroke and other neurovascular disease
  • Neurosurgeons who perform advanced surgical procedures for aneurysms, AVMs and other complex conditions
  • Interventional neurologists who perform minimally invasive endovascular procedures
  • Neuroradiologists who interpret brain and vascular imaging
  • Neurocritical care physicians who care for patients with life-threatening neurologic conditions
  • Rehabilitation specialists who help restore function and support recovery after stroke

Frequently Asked Questions About Neurovascular Care

What symptoms might indicate a neurovascular disorder like an aneurysm or AVM?

Symptoms may include:

  • Balance issues
  • Confusion
  • Dizziness
  • Seizures
  • Sudden severe headache
  • Trouble speaking
  • Vision changes
  • Weakness or numbness

Some brain aneurysms and AVMs don’t cause symptoms. We may only discover them during imaging or after bleeding occurs.

When should I seek emergency care for possible neurovascular symptoms?

Call 911 or seek emergency medical care immediately if you experience stroke symptoms, including:

  • Confusion
  • Difficulty walking
  • Facial drooping
  • Loss of vision
  • Sudden severe headache
  • Sudden weakness
  • Trouble speaking

Stroke is a medical emergency, and early treatment can greatly improve your outcome.

Can neurovascular disease be treated without surgery or with minimally invasive procedures?

Yes. We can treat many neurovascular conditions with medications or minimally invasive endovascular procedures rather than traditional surgery. Your treatment plan will depend on your diagnosis, the severity of your condition, your overall health and your personal goals.

What are the risks of untreated neurovascular disorders?

Without treatment, some neurovascular disorders can lead to stroke, brain hemorrhage, seizures, cognitive decline or worsening symptoms. Some of these conditions are life-threatening, which is why early evaluation and treatment are so important.

What is recovery like after treatment for a brain aneurysm or stroke?

Recovery is different for every person and depends on your diagnosis, treatment and overall health. Some patients recover quickly. Others may need rehabilitation, physical therapy, speech therapy and ongoing neurologic care to regain function over time.

Who is at highest risk for developing neurovascular disorders?

Not all neurovascular conditions are preventable. But several factors can increase your risk, including:

  • A sedentary lifestyle
  • Atrial fibrillation (AFib)
  • Diabetes
  • High blood pressure
  • High cholesterol
  • Obesity
  • Personal or family history of stroke or vascular disease
  • Smoking

Should I get a second opinion for a brain aneurysm or stroke diagnosis?

Many patients come to us for a second opinion for complex conditions, especially when considering surgery. Getting a second opinion can help you learn more about your diagnosis, explore all available treatment options and know what to expect in your care plan.

What should I bring to my first appointment?

Please bring any previous imaging studies, medical records, a current list of medications and notes from other specialists you’ve seen. Having this information allows our team to review your full history and make the most of your visit.

Will I need advanced imaging?

Most likely. Many patients benefit from advanced imaging because it provides a clearer picture of the brain’s blood vessel structure, blood flow and stroke risk. Your team will recommend imaging only when needed, based on your symptoms, diagnosis and medical history.

Can lifestyle changes reduce my stroke risk?

Yes. Healthy lifestyle habits can significantly reduce your risk of stroke. Your provider might talk to you about:

  • Controlling blood pressure, cholesterol and diabetes
  • Eating a heart-healthy diet
  • Quitting smoking
  • Staying physically active
  • Taking medications as prescribed

Stroke and Transient Ischemic Attack (TIA) Care

We identify and treat ischemic attacks to reduce the risk of recurrent strokes.

Learn more

USC Neuro Revascularization Center

We deliver expert care for complex neurovascular diseases, with a focus on preventing disability and improving your quality of life.

Learn more
Doctors holding a digital tablet and scans of a patient's brain
Doctors holding a digital tablet and scans of a patient's brain
Charles Liu, MD, PhD, a Keck Medicine neurosurgeon, shows a female patient a model of a brain and skull
Charles Liu, MD, PhD, a Keck Medicine neurosurgeon, shows a female patient a model of a brain and skull

Neurosurgery Care

Our dedicated neurosurgeons use minimally invasive methods whenever possible to treat a wide range of neurological conditions. 

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Neurological Care

Our neurologists and neurosurgeons are leaders in treating neurological disorders.

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Two male Keck Medicine of USC experts in Alzheimer's disease and other neurological disorders look into a microscope in an operating room
Two male Keck Medicine of USC experts in Alzheimer's disease and other neurological disorders look into a microscope in an operating room

World-Class Leadership

Our internationally renowned physicians and clinicians are dedicated to delivering high-quality patient care. We are leaders in cutting-edge treatments, breakthrough research and exceptional outcomes.

David Liebeskind, MD - Psychiatry & Neurology, Neurological Surgery - Keck Medicine of USC

David Sigmund Liebeskind, MD, MBA

Founding Co-Director, USC Neurovascular Center
A portrait of Dr. William J. Mack.

William J. Mack, MD

Founding Co-Director, USC Neurovascular Center
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