Trusted Treatment for Genetic Aortic and Vascular Disorders  

Our team of world-class physicians specializes in treating connective tissue disorders. Many of our doctors are involved in medical research related to connective tissue disease, working to help develop best medication management practices, safe surgical interventions and a deeper understanding of genetic variants that cause these diseases. Genetic aortic and vascular disorders are genetic conditions that affect the aorta and blood vessels. They raise the risk of aneurysms, dissections (when the inner layer of an artery tears) and other serious complications. These conditions include:  

• Bicuspid aortic valve 
• Familial thoracic aortic aneurysm/dissection 
• Loeys-Dietz syndrome 
• Marfan syndrome 
• Osteogenesis imperfecta 
• Turner syndrome 
• Vascular type, Ehlers-Danlos syndrome (vEDS) 

At the USC Genetic Aortic and Related Disorders Center, you’ll receive multidisciplinary care. Our team combines cardiovascular specialists, genetic evaluation and advanced imaging. With the ability to make these diagnoses early, we can offer personalized care and long-term monitoring for you and your family.

Common Symptoms of Genetic Aortic and Vascular Disorders  

Symptoms of genetic aortic and vascular disorders are based on a person’s condition and may be mild or absent for years. Some people may receive a diagnosis after a specialist discovers a family history. Because many of these conditions progress silently, genetic counseling and routine imaging are vital parts of prevention and early treatment. Common symptoms may include: 

• Abnormal bone and joint problems, such as club foot, pectus or scoliosis 
• Brain aneurysm 
• Chest, back or abdominal pain 
• Dizziness 
• Early onset aortic anuerysm or dissection 
• Fatigue 
• Gastrointestinal rupture 
• Heart palpitations 
• Shortness of breath 
• Spontaneous collapsed lung (pneumothorax) 
• Unexplained vascular complications 

Treatments We Offer for Genetic Aortic and Vascular Disorders  

Our team carefully tracks your changes over time. We work with you to decide on the safest timing for treatment and focus on long-term outcomes and quality of life. Your personalized treatment for a genetic aortic and vascular disorder may include: 

• Advanced surgical or minimally invasive procedures  
• Lifestyle guidance 
• Medications to reduce stress on the aorta 
• Regular imaging and monitoring 

In addition to treating you, we can also help with familial genetic testing to determine whether any of your family members also carry genetic variants that cause disease. 

Why Choose Us for Genetic Aortic and Vascular Disorders Care

We offer multidisciplinary care that integrates cardiology, vascular surgery and genetic expertise.

We use advanced imaging and genetic evaluation for early detection and risk assessment.

You receive personalized monitoring and treatment plans based on your condition and family history.

Our team has vast experience managing rare and complex genetic aortic and vascular disorders.

You receive ongoing support for patients and families navigating lifelong inherited conditions.