Ryan C. Knoper, MD

Ryan C. Knoper, MD, is a cardiac surgeon with Keck Medicine of USC who treats a broad range of adult heart conditions.

Dr. Knoper has expertise in advanced coronary artery bypass techniques, including multiple arterial grafting and anaortic off-pump surgeries. He also has unique specialization in pulmonary thromboendarterectomy for chronic thromboembolic pulmonary hypertension (CTEPH) and septal myectomy for hypertrophic obstructive cardiomyopathy (HOCM). He performs surgery for atrial fibrillation, including minimally invasive procedures for difficult-to-treat AFib cases. He also treats many variations of valvular heart disease with procedures including TAVR, SAVR, mitral valve replacement, mitral valve repair and aortic root replacement. In addition, he supports patients in need of LVAD, ECMO, heart transplantation or complex/repeat heart surgery.

Dr. Knoper received his medical degree from the University of Arizona in Tucson. He completed a general surgery residency at Rush University Medical Center/John H. Stroger, Jr., Hospital of Cook County in Chicago, followed by a thoracic surgery residency at the University of Minnesota in Minneapolis.

Dr. Knoper serves as a clinical assistant professor of surgery at the Keck School of Medicine of USC, where his research focuses on improving the quality of surgical outcomes.

He believes that trust is the foundation of the physician and patient relationship. When he’s not working, he enjoys spending time with his family and in the outdoors.