William J. Mack

Associate Professor of Neurological Surgery

Areas of treatment:

Arteriovenous Malformation
Carotid Artery Disease
Arteriovenous Fistula
Vertebral Fracture
Degenerative Spine Disease
Brain Tumors


  • Neurosurgery


  • Department of Neurological Surgery


  • English

William J. Mack, MD

Associate Professor of Neurological Surgery

Practicing locations:

  • Keck Hospital of USC
  • USC Healthcare Center 2

About this doctor:

William Mack, MD, received his bachelor degree with honors from Cornell University. He then attended Columbia University, College of Physicians and Surgeons, where he graduated from medical school and completed Neurosurgical residency training. During residency, he spent one year performing a post-doctoral cerebrovascular research fellowship under Drs. David J. Pinsky and E. Sander Connolly Jr. at Columbia University. Following residency, Dr. Mack completed an Interventional Neuroradiology fellowship at UCLA.

Dr. Mack’s major areas of clinical interest are stroke, brain aneurysms, subarachnoid hemorrhage, arteriovenous malformations (AVMs), arteriovenous fistulas, cavernous malformations, carotid artery disease, intracranial stenosis, and brain tumors. Dr. Mack performs both open surgery and minimally invasive, endovascular procedures for cerebrovascular disorders.

Dr. Mack is the Principal Investigator and Director of the Cerebrovascular Laboratory in the Zilkha Neurogenetic Institute. He has received numerous local, regional, and national grants in support of his research efforts. Dr. Mack’s scientific interests are focused on translational efforts to treat ischemic and hemorrhagic stroke. Laboratory investigations concentrate on the pathophysiology of stroke and inflammatory modulation. Using the information and experience gained in the laboratory, Dr. Mack is working to develop new technologies, techniques, and therapies to directly improve the clinical care administered to stroke patients.


Doctor of Medicine, Columbia University College of Physicians and Surgeons, 2001


Columbia University College of Physicians & Surgeons, General Surgery, 2001 - 2002


Columbia University College of Physicians & Surgeons, Neurological Surgery, 2002 - 2008


UCLA David Geffen School of Medicine, Interventional Neuroradiology, 2008 - 2010


American Board of Neurological Surgery: Board Eligible

Professional society memberships:

Congress of Neurological Surgeons
American Association of Neurological Surgeons
Society of Neurointerventional Surgery
American Heart Association


Alpha Omega Alpha Honor Society, 2001
Phi Beta Kappa, 1996