Stephen B. Gruber

Director, USC Norris Comprehensive Cancer Center Professor of Medicine, Keck School of Medicine of USC
Stephen B. Gruber, MD,PhD, MPH

Areas of treatment:

Cancer genetics
Cancer epidemiology
Genetic epidemiology
Molecular epidemiology


  • Oncology


  • Department of Medicine


  • English

Stephen B. Gruber, MD, PhD, MPH

Director, USC Norris Comprehensive Cancer Center
Professor of Medicine, Keck School of Medicine of USC

Practicing location:

  • USC Norris Comprehensive Cancer Center and Hospital

About this doctor:

Stephen B. Gruber, MD, PhD, MPH, Director of the USC Norris Comprehensive Cancer Center, is a Professor of Medicine at the Keck School of Medicine, and the H. Leslie Hoffman and Elaine S. Hoffman Chair in Cancer Research.

Dr. Gruber is a board certified medical oncologist, cancer geneticist and epidemiologist whose research focuses on genetic and environmental contributions to cancer. His particular research interests include the genetic epidemiology of cancer, with emphasis on colorectal cancer; the molecular pathogenesis of cancer, integrated with genetic epidemiology; methods in genetic and molecular epidemiology; and clinical cancer genetics and translational research in cancer prevention. The goal of his research is to find new ways to prevent cancer and to improve treatment and care for cancer patients.

Dr. Gruber obtained his bachelor’s degree from the University of Pennsylvania in 1984 and subsequently a master of public health degree from Yale University in 1986. After completing his doctorate degree in Epidemiology at Yale in 1988, Dr. Gruber enrolled in the University of Pennsylvania Medical School and obtained his medical degree in 1992, where he also completed his internship and residency. He completed fellowships in medical oncology at Johns Hopkins Hospital and in clinical medical genetics at the University of Michigan.

He has received a variety of honors and awards and is the author of 158 peer-reviewed publications, many in very high quality journals attesting to his standing in the field of cancer genetics, particularly as it relates to colorectal cancer. In addition to serving on editorial boards for several professional journals, Dr. Gruber is active in national organizations. Since 2005, he has been chair of the Colorectal Family Registries Advisory Panel for the National Cancer Institute and for the past three years chaired the Cancer Genetics Education Committee of the American Society of Clinical Oncology.


Doctor of Medicine, University of Pennsylvania, 1992


University of Pennsylvania, Internal Medicine, 1992 - 1993


University of Pennsylvania, Internal Medicine, 1993 - 1994


University of Michigan, Medical Genetics, 1997 - 1999
Johns Hopkins University, Medical Oncology, 1994 - 1997


Castle Connolly "Top Doctor,” 2015